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Metronidazole is often a nitroimidazole and should be used with care in clients with evidence of, or record of blood dyscrasia.
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Distinct research of metronidazole concentrations in human milk adhering to intravaginally administered metronidazole have not been executed. Nevertheless, metronidazole is secreted in human milk in concentrations just like those located in plasma subsequent oral administration of metronidazole.
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There's been no knowledge to this point with using METROGEL-VAGINAL in Expecting patients. Metronidazole crosses the placental barrier and enters the fetal circulation promptly. No fetotoxicity or teratogenicity was observed when metronidazole was administered orally to pregnant mice at 6 times the encouraged human dose (based on mg/m2); nevertheless, in one tiny analyze in which the drug was administered intraperitoneally, some intrauterine deaths were being noticed. The connection of these findings on the drug is not known.
Knowledge from perfectly-managed trials directly evaluating metronidazole administered orally to metronidazole administered vaginally are not readily available.